READY TO START MAYZENT®?

Great! Once your doctor submits a Start Form, you'll be automatically enrolled in our support program, and paired with a dedicated Alongside™ MAYZENT Coordinator.

Alongside MAYZENT is here for personalized support as you start and continue on treatment—in a way that works for you.

Great! Once your doctor submits a Start Form, you'll be automatically enrolled in our support program, and paired with a dedicated Alongside™ MAYZENT Coordinator.

Alongside MAYZENT is here for personalized support as you start and continue on treatment—in a way that works for you.

THERE ARE 2 STEPS TO COMPLETE BEFORE STARTING MAYZENT

STEP 1—PRETESTS

BLOOD TESTS

Before beginning MAYZENT, a few simple blood tests are needed that will help:

  • Identify your genotype* to determine if MAYZENT is right for you, and which dose to take

  • Check your liver function

  • Obtain a complete blood count

To make these simple blood tests as easy as possible, your doctor has options to complete the testing: at your doctor's office, at a single in-home visit, or at any local LabCorp or Quest Diagnostics location.†

No matter which option you choose, Novartis will cover the cost of genetic type testing.

EYE EXAM

  • An eye exam will look for preexisting conditions and help monitor potential changes

ECG

  • An electrocardiogram (ECG) will test whether you will need to take extra care if you have certain heart conditions

STEP 2—START TAKING MAYZENT

  • Once pretests are finished and dosage is confirmed, your treatment with MAYZENT can begin immediately, for all commercially insured and approved government-insured patients
  • You'll begin titration. That means you'll slowly increase your dose for 5 days
    • Then, you'll take your regular daily MAYZENT dose, as prescribed
    • Titration is important, so do not skip this step. Your Alongside MAYZENT Coordinator will be there to walk you through this process

Your Welcome Kit has everything you need to get started, including:

  • Your titration and maintenance doses for the first month
  • A step-by-step guide to titration and instructions for scheduling a video chat demonstration with your Coordinator

Although most people starting MAYZENT will not need to be monitored after taking their first dose, it's required for some people.‡ Your doctor will tell you if it's necessary.

*A CYP2C9 genotype blood test is available at no cost. Limitations may apply. The cost of the test may not be billed to any third-party payer. No purchase required. Program subject to termination or modification at any time.

†Listed services provided via a Program-sponsored medical facility or at home may be free for commercially insured and uninsured patients starting MAYZENT. Offer not valid for services (i) performed in RI, (ii) for which payment may be made in whole or in part under federal or state health care programs, including, but not limited to, Medicare or Medicaid, or (iii) where prohibited by law. There is a cash-pay option for residents of RI choosing to use a Program-sponsored medical facility. No purchase required. The Program is subject to termination or modification at any time. For questions regarding covered services, please contact your Alongside Coordinator.

‡For certain cardiac risk factors, for example a history of heart attacks or heart failure, you may have to be monitored for a period of 6 hours after taking your first dose of MAYZENT. An ECG should be conducted at the end of the observation period.

ALONGSIDE MAYZENT IS HERE TO HELP GET YOU STARTED, AND WHENEVER YOU NEED SUPPORT AFTER THAT

A Start Form gets the ball rolling on treatment and automatically enrolls you in Alongside MAYZENT. Once you're in the program, you'll be paired with a dedicated Coordinator.

ALONGSIDE MAYZENT IS HERE TO HELP GET YOU STARTED, AND WHENEVER YOU NEED SUPPORT AFTER THAT

A Start Form gets the ball rolling on treatment and automatically enrolls you in Alongside MAYZENT. Once you're in the program, you'll be paired with a dedicated Coordinator.

FIND OUT MORE ABOUT TAKING MAYZENT

Learn about patient support and how to take MAYZENT in the Ready to Start MAYZENT Brochure.

DOWNLOAD

FIND OUT MORE ABOUT TAKING MAYZENT

Learn about patient support and how to take MAYZENT in the Ready to Start MAYZENT Brochure.

DOWNLOAD

TALK TO YOUR DOCTOR TO SEE IF MAYZENT COULD BE RIGHT FOR YOU

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INDICATION AND IMPORTANT SAFETY INFORMATION

IMPORTANT SAFETY INFORMATION

Do not take MAYZENT if you:

  • have a CYP2C9*3/*3 genotype. Before starting treatment with MAYZENT, your CYP2C9 genotype should be determined by your health care provider. Ask your health care provider if you are not sure.

  • have had a heart attack, chest pain called unstable angina, stroke or mini-stroke (transient ischemic attack or TIA), or certain types of heart failure in the last 6 months

What is MAYZENT® (siponimod) tablets?:

MAYZENT is a prescription medicine that is used to treat relapsing forms of multiple sclerosis, to include clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease, in adults.

It is not known if MAYZENT is safe and effective in children.

  • have certain types of heart block or irregular or abnormal heartbeat (arrhythmia), unless you have a pacemaker

MAYZENT may cause serious side effects, including:

  1. Slow heart rate (bradycardia or bradyarrhythmia) when you start taking MAYZENT. MAYZENT can cause your heart rate to slow down, especially after you take your first dose. You should have a test to check the electrical activity of your heart called an electrocardiogram (ECG) before you take your first dose of MAYZENT.

    During the initial updosing period (4 days for the 1-mg daily dose or 5 days for the 2-mg daily dose), if you miss 1 or more doses of MAYZENT, you need to restart the updosing. Call your health care provider if you miss a dose of MAYZENT.

  2. Infections. MAYZENT can increase your risk of serious infections that can be life-threatening and cause death. MAYZENT lowers the number of white blood cells (lymphocytes) in your blood. This will usually go back to normal within 3 to 4 weeks of stopping treatment. Your health care provider should review a recent blood test of your white blood cells before you start taking MAYZENT.

    Call your health care provider right away if you have any of these symptoms of an infection during treatment with MAYZENT and for 3 to 4 weeks after your last dose of MAYZENT:

    • fever

    • tiredness

    • body aches

    • chills

    • nausea

    • vomiting

    • headache with fever, neck stiffness, sensitivity to light, nausea, confusion (these may be symptoms of meningitis, an infection of the lining around your brain and spine)

  3. A problem with your vision called macular edema. Macular edema can cause some of the same vision symptoms as a multiple sclerosis (MS) attack (optic neuritis). You may not notice any symptoms with macular edema. If macular edema happens, it usually starts in the first 1 to 4 months after you start taking MAYZENT. Your health care provider should test your vision before you start taking MAYZENT and any time you notice vision changes during treatment with MAYZENT. Your risk of macular edema is higher if you have diabetes or have had an inflammation of your eye called uveitis.

    Call your health care provider right away if you have any of the following: blurriness or shadows in the center of your vision, a blind spot in the center of your vision, sensitivity to light, or unusually colored (tinted) vision.

Before taking MAYZENT, tell your health care provider about all of your medical conditions, including if you:

  • have an irregular or abnormal heartbeat

  • have a history of stroke or other diseases related to blood vessels in the brain

  • have breathing problems, including during your sleep

  • have a fever or infection, or you are unable to fight infections due to a disease or are taking medicines that lower your immune system. Tell your health care provider if you have had chickenpox or have received the vaccine for chickenpox. Your health care provider may do a blood test for chickenpox virus. You may need to get the full course of vaccine for chickenpox and then wait 1 month before you start taking MAYZENT.

  • have slow heart rate

  • have liver problems

  • have diabetes

  • have eye problems, especially an inflammation of the eye called uveitis

  • have high blood pressure

  • are pregnant or plan to become pregnant. MAYZENT may harm your unborn baby. Talk to your health care provider right away if you become pregnant while taking MAYZENT or if you become pregnant within 10 days after you stop taking MAYZENT.

    • If you are a woman who can become pregnant, you should use effective birth control during your treatment with MAYZENT and for at least 10 days after you stop taking MAYZENT.

  • are breastfeeding or plan to breastfeed. It is not known if MAYZENT passes into your breast milk. Talk to your health care provider about the best way to feed your baby if you take MAYZENT.

Tell your health care provider about all the medicines you take, including prescription medicines, over-the-counter medicines, vitamins, and herbal supplements. Especially tell your health care provider if you take medicines to control your heart rhythm (anti-arrhythmics), or blood pressure (antihypertensives), or heart beat (such as calcium channel blockers or beta-blockers); take medicines that affect your immune system, such as beta-interferon or glatiramer acetate, or any of these medicines that you took in the past.

Tell your health care provider if you have recently received a live vaccine. You should avoid receiving live vaccines during treatment with MAYZENT. MAYZENT should be stopped 1 week before and for 4 weeks after receiving a live vaccine. If you receive a live vaccine, you may get the infection the vaccine was meant to prevent. Vaccines may not work as well when given during treatment with MAYZENT.

MAYZENT may cause possible side effects, including:

  • increased blood pressure. Your health care provider should check your blood pressure during treatment with MAYZENT.

  • liver problems. MAYZENT may cause liver problems. Your health care provider should do blood tests to check your liver before you start taking MAYZENT. Call your health care provider right away if you have any of the following symptoms of liver problems:

    • nausea

    • vomiting

    • stomach pain

    • tiredness

    • loss of appetite

    • your skin or the whites of your eyes turn yellow

    • dark urine

  • breathing problems. Some people who take MAYZENT have shortness of breath. Call your health care provider right away if you have new or worsening breathing problems.

  • swelling and narrowing of the blood vessels in your brain. A condition called PRES (Posterior Reversible Encephalopathy Syndrome) has happened with drugs in the same class. Symptoms of PRES usually get better when you stop taking MAYZENT. However, if left untreated, it may lead to a stroke. Call your health care provider right away if you have any of the following symptoms: sudden severe headache, sudden confusion, sudden loss of vision or other changes in vision, or seizure.

  • severe worsening of multiple sclerosis after stopping MAYZENT. When MAYZENT is stopped, symptoms of MS may return and become worse compared to before or during treatment. Always talk to your doctor before you stop taking MAYZENT for any reason. Tell your health care provider if you have worsening symptoms of MS after stopping MAYZENT.

The most common side effects of MAYZENT include: headache, high blood pressure (hypertension), and abnormal liver tests.

These are not all of the possible side effects of MAYZENT. Call your doctor for medical advice about side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

What is MAYZENT® (siponimod) tablets?

MAYZENT is a prescription medicine that is used to treat relapsing forms of multiple sclerosis, to include clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease, in adults.

It is not known if MAYZENT is safe and effective in children.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please see full Prescribing Information, including Medication Guide.